ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0016.5-18 | Basic Science - Bone | ESPEYB16

5.18. Developmental origin, functional maintenance and genetic rescue of osteoclasts

CE Jacome-Galarza , GI Percin , JT Muller , E Mass , T Lazarov , J Eitler , M Rauner , VK Yadav , L Crozet , M Bohm , PL Loyher , G Karsenty , C Waskow , F Geissmann

Abstract: Nature. 2019 Apr;568(7753):541–545.In brief: Murine knockout studies unravel the developmental origin of osteoclasts in embryonic, erythro-myeloid progenitors, acquiring exceptional longevity by constant fusion with monocytes and rejuvenation of cellular nucleii throughout postnatal life.Comment: Osteoclast function is essentia...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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